A new study reveals the mechanism of action of the immune guidance system in the body

A new study by researchers at the Grossman School of Medicine at New York University shows that when the immune response begins, the molecule responsible for moving immune cells in the bloodstream quickly changes its position, as researchers say this indirectly amplifies the attack on foreign microbes or body tissues, according to a published report. On the MedicalXpress website

For the first time, researchers at New York University's Grossman School of Medicine have shown in rat experiments that S1P levels in the lymph nodes increase as the immune response escalates, as this activation of immune cells can cause inflammation, swelling, or death of the target cells.

"While more tests are needed, our findings increase the likelihood that S1P levels will need to be controlled to either enhance or reduce the body's immune response, as needed," said lead author Audrey Baines.

Moreover, the researchers found that when lymph node levels of S1P increased, this stimulated T cells to remain in the lymph nodes with a longer time to mature to become fully armed, and these mature T cells could attack virus-infected cells or healthy cells as part of autoimmune diseases.

The researchers said that their findings could also explain why patients with multiple sclerosis sometimes have sudden severe relapses, as the T cells present in the lymph nodes for a long period of time are released to attack the nerves of the body, which is a major feature of the disease.